Digital flood-inundation maps for a 3.95-mile reach of the Saluda River from approximately 815 feet downstream from Old Easley Bridge Road to approximately 150 feet downstream from Saluda Lake Dam near Greenville, South Carolina, were developed by the U.S. Geological Survey (USGS). The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Saluda River near Greenville, South Carolina (station 02162500). Current conditions at the USGS streamgage may be obtained through the National Water Information System Web site at http://waterdata.usgs.gov/sc/nwis/uv/?site_no=02162500&PARAmeter_cd=00065,00060,00062. The National Weather Service (NWS) forecasts flood hydrographs at many places that are often collocated with USGS streamgages. Forecasted peak-stage information is available on the Internet at the NWS Advanced Hydrologic Prediction Service (AHPS) flood-warning system Web site (http://water.weather.gov/ahps/) and may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation.In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated using the most current stage-streamflow relations at USGS streamgage station 02162500, Saluda River near Greenville, South Carolina. The hydraulic model was then used to determine water-surface profiles for flood stages at 1.0-foot intervals referenced to the streamgage datum and ranging from approximately bankfull to 2 feet higher than the highest recorded water level at the streamgage. The simulated water-surface profiles were then exported to a geographic information system, ArcGIS, and combined with a digital elevation model (derived from Light Detection and Ranging [LiDAR] data with a 0.6-foot vertical Root Mean Square Error [RMSE] and a 3.0-foot horizontal RMSE), using HEC-GeoRAS tools in order to delineate the area flooded at each water level. The availability of these maps, along with real-time stage data from the USGS streamgage station 02162500 and forecasted stream stages from the NWS, can provide emergency management personnel and residents with information that is critical during flood-response and flood-recovery activities, such as evacuations, road closures, and disaster declarations.