The U.S. Geological Survey's (USGS) Sixth Biennial Geographic Information Science Workshop April 24 - 28, 2006, at the Denver Federal Center in Denver, Colorado, provides a unique opportunity for multi-disciplinary Geographic Information Systems (GIS) and associated scientific professionals to share, learn, present, and discuss a wide variety of geospatial-related topics. Information is exchanged through a series of plenary sessions, hands-on technical workshops, user and commercial vendor demonstrations, lecture and poster sessions, and specialty meetings. Workshop attendance is limited to Department of Interior (DOI) and USGS employees and contractors; however, plenary, hands-on, and lecture sessions have presenters from other Federal agencies, numerous commercial vendors, universities, and several consortia. Over 175 participants are expected to attend the Workshop. Several prominent speakers are featured at this Workshop. Monday evening Star Guest Speaker and National Aeronautics and Space Administration (NASA) Astronaut Captain Dominic Gorie will talk about his experiences as a veteran of three space flights and over 32 days in space, including the NASA Space Shuttle Radar Topography Mission that mapped more than 47 million miles of the Earth's land surface. Selected as an astronaut candidate by NASA in December 1994, Captain Gorie is currently Chief of the Astronaut Shuttle Branch. Monday evening also features a town hall meeting with Geographic Information Office (GIO) leaders Karen Siderelis, Kevin Gallagher, Bob Pierce, Steve Guptill, Mark DeMulder, John Mahoney, and Mark Negri, who will discuss changes and activities within the GIO in an open discussion format. Tuesday plenary sessions feature keynote speaker Dr. P. Patrick Leahy, Acting USGS Director. Dr. Leahy holds undergraduate and graduate degrees in geology (1968) and geophysics (1970) from Boston College. In 1979, he received his doctorate in geology from Rensselaer Polytechnic Institute, where he specialized in regional ground-water studies and hydraulics. Dr. Leahy has been with the USGS since 1974, and has held various technical and managerial positions, including Associate Director for Geology and Chief of the National Water-Quality Assessment (NAWQA) Program. Dr. Leahy will be discussing a broad range of topics including Bureau accomplishments, initiatives, and budgets. The purpose of this proceedings volume is to serve as an activity reference for Workshop attendees as well as an archive of technical abstracts submitted, presented, and discussed at the Workshop. Author, co-author, and presenter names, affiliations, and contact information are listed with presentation titles along with submitted abstracts. Some hands-on sessions are offered twice. In these instances, abstracts submitted for publication are presented in the proceedings on both days they are offered. All acronyms used in these proceedings are explained in the text of each abstract. The term 'ArcGIS' refers to an integrated collection of GIS software products produced by Environmental Systems Research Institute, Inc. (ESRI).