Antimycin: Uptake, distribution, and elimination in brown bullheads (Ictalurus nebulosus)
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Abstract
Radioactive antimycin was readily taken up in bile and tissues of brown bullheads (Ictalurus nebulosus) exposed to 0.045 μg/ml of 14C-antimycin for as long as 48 h. Bile contained the most and blood the least radioactivity at all sampling periods. The highest concentration of 14C-antimycin in muscle was 0.12 μg/g, after 12 h of exposure. The average amount of 14C-antimycin per fish was 0.94 μg/g. The 14C-antimycin concentration decreased with the elapse of time in the muscle and in samples of combined head, skin, and viscera. The concentration of l4C-antimycin in the exposure solution decreased from 0.045 μg/ml to 0.015 μg/ml after 12 h and 0.010 μg/ml after 48 h. The initial half-life of 14C-antimycin in the exposure solution was about 6.5 h. A second group of fish was exposed to 0.045 μg/ml of l4C-antimycin for 48 h and then transferred to antimycin-free, flowing water for up to 96 h. The 14C-activity decreased in muscle tissue from 0.11 μg/g to 0.05 μg/g in 96 h. Half-life of 14C-antimycin was about 75 h in muscle and 61 h in the combined head, skin, and viscera.
Suggested Citation
Schultz, D., and Harman, P., 1976, Antimycin: Uptake, distribution, and elimination in brown bullheads (Ictalurus nebulosus): Journal of the Fisheries Research Board of Canada, v. 33, no. 5, p. 1121-1129, https://doi.org/10.1139/f76-140.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Antimycin: Uptake, distribution, and elimination in brown bullheads (Ictalurus nebulosus) |
| Series title | Journal of the Fisheries Research Board of Canada |
| DOI | 10.1139/f76-140 |
| Volume | 33 |
| Issue | 5 |
| Year Published | 1976 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | 9 p. |
| First page | 1121 |
| Last page | 1129 |