Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus)
Drug Metabolism and Disposition
By: G. R. Stehly and S. M. Plakas
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Abstract
The pharmacokinetics, tissue distribution, and metabolism of 1-naphthol were examined in the channel catfish (Ictalurus punctatus ). After oral dosing, peak plasma concentrations of 1-naphthol occurred at 1 hr; parent compound made up less than 15% of the total radioactivity, and the bioavailability was 32%. Plasma protein binding was 92% and was independent of concentration. 1-Naphthol and metabolites were rapidly eliminated from the tissues after oral dosing.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus) |
| Series title | Drug Metabolism and Disposition |
| Volume | 20 |
| Issue | 1 |
| Year Published | 1992 |
| Language | English |
| Publisher | U.S. Food and Drug Administration |
| Publisher location | Dauphin Island, AL |
| Contributing office(s) | Upper Midwest Environmental Sciences Center |
| Description | pp. 70-73 |
| Larger Work Type | Article |
| Larger Work Subtype | Journal Article |
| Larger Work Title | Drug Metabolism and Disposition |
| First page | 70 |
| Last page | 73 |