Tissue distribution and elimination of radiolabelled methyltestosterone fed to adult blue tilapia
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Abstract
Radioactivity levels in 10 tissues were monitored for 21 days after adult (1-year-old) blue tilapia, Oreochromis aureus, were fed a single meal of a diet containing 30 μg unlabelled methyltestosterone (MT) per gram of feed and radiolabelled MT (3H-labelled steroid nucleus and 14C-labelled 17α-methyl group). Radioactivity was highest in all tissues 6–12 h after the feeding; about 90% of the radioactivity was in the digestive tract, liver, gall bladder, and kidney. Radioactivity declined nearly 90% by 4 days and only 0.5% of original radioactivity (67 ng/g of fish) remained after 21 days. Half of the remaining exogenous hormone was in digestive and excretory tissues; concentrations in muscle were less than 1 ng/g of tissue. Ratios of 3H:14C in tissues were similar to those incorporated in the diet and suggested that the 17α-methyl group was not removed during metabolism.
Suggested Citation
Goudie, C.A., Shelton, W.L., Parker, N.C., 1986, Tissue distribution and elimination of radiolabelled methyltestosterone fed to adult blue tilapia: Aquaculture, v. 58, no. 3/4, p. 227-240, https://doi.org/10.1016/0044-8486(86)90088-8.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Tissue distribution and elimination of radiolabelled methyltestosterone fed to adult blue tilapia |
| Series title | Aquaculture |
| DOI | 10.1016/0044-8486(86)90088-8 |
| Volume | 58 |
| Issue | 3/4 |
| Year Published | 1986 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Leetown Science Center |
| Description | 14 p. |
| First page | 227 |
| Last page | 240 |