Stimulation of coho salmon growth by insulin-like growth factor I
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Abstract
The effect of insulin-like growth factor I on growth rate of coho salmon (Oncorhynchus kisutch) was examined. Juvenile coho salmon received implants of osmotic minipumps containing recombinant bovine insulin-like growth factor I (rbIGF-I) or saline for a period of 3 to 4 weeks. High doses of rbIGF-I (>0.13 μg · g−1 · d−1) resulted in hypoglycemia and death. In 2-year-old coho salmon, 0.09 μg · g−1 · d−1 rbIGF-I administered for 25 days doubled linear growth rate and increased growth rate in weight by 40%. In rapidly growing, 1-year-old coho salmon, growth rate was not altered by rbIGF-I at 0.01 or 0.05 μg · g−1 · d−1 for 31 days. In ration-limited fish exhibiting slow growth in the control group, rbIGF-I (0.02 to 0.12 μg · g−1 · d−1) increased linear growth rate by up to threefold and growth rate in weight by up to fourfold. The results indicate that exogenous treatment with mammalian IGF-I can stimulate coho salmon growth under some conditions, and that endogenous IGF-I may be an important factor in regulating growth of teleosts.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Stimulation of coho salmon growth by insulin-like growth factor I |
| Series title | General and Comparative Endocrinology |
| DOI | 10.1016/0016-6480(92)90064-Q |
| Volume | 86 |
| Issue | 3 |
| Year Published | 1992 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Leetown Science Center |
| Description | 9 p. |
| First page | 398 |
| Last page | 406 |
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