Stimulation of coho salmon growth by insulin-like growth factor I
Links
- More information: Publisher Index Page (via DOI)
- Download citation as: RIS | Dublin Core
Abstract
The effect of insulin-like growth factor I on growth rate of coho salmon (Oncorhynchus kisutch) was examined. Juvenile coho salmon received implants of osmotic minipumps containing recombinant bovine insulin-like growth factor I (rbIGF-I) or saline for a period of 3 to 4 weeks. High doses of rbIGF-I (>0.13 μg · g−1 · d−1) resulted in hypoglycemia and death. In 2-year-old coho salmon, 0.09 μg · g−1 · d−1 rbIGF-I administered for 25 days doubled linear growth rate and increased growth rate in weight by 40%. In rapidly growing, 1-year-old coho salmon, growth rate was not altered by rbIGF-I at 0.01 or 0.05 μg · g−1 · d−1 for 31 days. In ration-limited fish exhibiting slow growth in the control group, rbIGF-I (0.02 to 0.12 μg · g−1 · d−1) increased linear growth rate by up to threefold and growth rate in weight by up to fourfold. The results indicate that exogenous treatment with mammalian IGF-I can stimulate coho salmon growth under some conditions, and that endogenous IGF-I may be an important factor in regulating growth of teleosts.
Suggested Citation
McCormick, S., Kelley, K., Young, G., Nishioka, R.S., and Bern, H.A., 1992, Stimulation of coho salmon growth by insulin-like growth factor I: General and Comparative Endocrinology, v. 86, no. 3, p. 398-406, https://doi.org/10.1016/0016-6480(92)90064-Q.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | Stimulation of coho salmon growth by insulin-like growth factor I |
| Series title | General and Comparative Endocrinology |
| DOI | 10.1016/0016-6480(92)90064-Q |
| Volume | 86 |
| Issue | 3 |
| Year Published | 1992 |
| Language | English |
| Publisher | Elsevier |
| Contributing office(s) | Leetown Science Center |
| Description | 9 p. |
| First page | 398 |
| Last page | 406 |