An automated approach to Litchfield and Wilcoxon's evaluation of dose–effect experiments using the R package LW1949
Environmental Toxicology and Chemistry
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Abstract
The authors developed a package, LW1949, for use with the statistical software R to automatically carry out the manual steps of Litchfield and Wilcoxon's method of evaluating dose–effect experiments. The LW1949 package consistently finds the best fitting dose–effect relation by minimizing the chi-squared statistic of the observed and expected number of affected individuals and substantially speeds up the line-fitting process and other calculations that Litchfield and Wilcoxon originally carried out by hand. Environ Toxicol Chem 2016;9999:1–4. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.
| Publication type | Article |
|---|---|
| Publication Subtype | Journal Article |
| Title | An automated approach to Litchfield and Wilcoxon's evaluation of dose–effect experiments using the R package LW1949 |
| Series title | Environmental Toxicology and Chemistry |
| DOI | 10.1002/etc.3490 |
| Volume | 35 |
| Issue | 12 |
| Publication Date | May 13, 2016 |
| Year Published | 2016 |
| Language | English |
| Publisher | SETAC |
| Publisher location | New York, NY |
| Contributing office(s) | Great Lakes Science Center |
| Description | 4 p. |
| First page | 3058 |
| Last page | 3061 |
| Online Only (Y/N) | N |
| Additional Online Files (Y/N) | N |